Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice.

ABSTRACT: The development of animal models for COVID-19 is essential for basic research and drug/vaccine screening. Previously reported COVID-19 animal models need to be established under a high biosafety level condition for the utilization of live SARS-CoV-2, which greatly limits its application in routine research. Here, we generate a mouse model of COVID-19 under a general laboratory condition that captures multiple characteristics of SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) observed in humans. Briefly, human ACE2-transgenic (hACE2) mice were intratracheally instilled with the formaldehyde-inactivated SARS-CoV-2, resulting in a rapid weight loss and detrimental changes in lung structure and function. The pulmonary pathologic changes were characterized by diffuse alveolar dama

SUBMITTER: Bi Z 

PROVIDER: S-EPMC8705082 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature