Combined integrin α_vβ₃ and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.

ABSTRACT: The integrin α_vβ₃ receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular endothelial cells and glioma cells. RGD tripeptide and Lf can specifically bind with integrin α_vβ₃ receptor and LfR, respectively. In our study, RGD and Lf dual-modified liposomes loaded with docetaxel (DTX) were designed to enhance the brain targeting effect and treatment of glioma. Our in vitro studies have shown that RGD-Lf-LP can significantly enhance the cellular uptake of U87 MG cells and human cerebral microvascular endothelial cells (hCMEC/D3) when compared to RGD modified liposomes (RGD-LP) and Lf modified liposomes (Lf-LP). Free RGD and Lf competitively reduced the cellular uptake of RGD-Lf-LP, in particular, free RGD played a mai

SUBMITTER: Qi N 

PROVIDER: S-EPMC8705194 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature