Cerebral small vessel disease, cardiovascular risk factors, and future walking speed in old age: a population-based cohort study.

ABSTRACT:

Background

The purpose of this study was to examine the associations between combined and individual cerebral small vessel disease (cSVD) markers on future walking speed over 9 years; and to explore whether these associations varied by the presence of cardiovascular risk factors (CRFs).

Methods

This population-based cohort study included 331 adults, aged ≥60 years, without limitation in walking speed (≥0.8 m/s). At baseline, cSVD markers, including white matter hyperintensities (WMH), lacunes, and perivascular spaces (PVS), were assessed on magnetic resonance imaging. The modifiable CRFs (physical inactivity, heavy alcohol consumption, smoking, hypertension, high total cholesterol, diabetes, and overweight/obese) were combined into a score. The association between baseline c

SUBMITTER: Heiland EG 

PROVIDER: S-EPMC8705459 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature