Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections.

ABSTRACT:

Background

There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects.

Methods

Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro.

Results

While IFNs alone were insufficient to completely abolish replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IFNα, in combination with remdesivir, EIDD-2801, camostat, cycloheximide, or convalescent serum, proved to be more effective. Transcriptome and metabolomic analyses revealed that the IFNα-remdesivir combination suppressed SARS-CoV-2-mediated changes in Calu-3 cells and lung organoids, although it altered the homeostasis of uninfected cells and organoids. We also demonstrated that IFNα combinations with sof

SUBMITTER: Ianevski A 

PROVIDER: S-EPMC8705725 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature