Near-Wall Aggregation of Amyloidogenic Aβ 1-40 Peptide: Direct Observation by the FRET.

ABSTRACT: The formation of amyloid fibrils is one of the variants of the self-organization of polypeptide chains. For the amyloid aggregation, the solution must be oversaturated with proteins. The interface of the liquid (solution) and solid (vessel walls) phases can trigger the adsorption of protein molecules, and the resulting oversaturation can initiate conformational transitions in them. In any laboratory experiment, we cannot exclude the presence of surfaces such as the walls of vessels, cuvettes, etc. However, in many works devoted to the study of amyloid formation, this feature is not considered. In our work, we investigated the behavior of the Aβ 1-40 peptide at the water-glass, water-quartz, and water-plastic interface. We carried out a series of simple experiments and showed that the Aβ 1-

SUBMITTER: Katina N 

PROVIDER: S-EPMC8706126 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature