Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment.

ABSTRACT: Age-related macular degeneration (AMD) is an incurable disease associated with aging that destroys sharp and central vision. Increasing evidence implicates both systemic and local inflammation in the pathogenesis of AMD. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is currently the first-line therapy for choroidal neovascularization in AMD patients. However, a high number of patients do not show satisfactory responses to anti-VEGF treatment after three injections. Predictive treatment response models are one of the most powerful tools for personalized medicine. Therefore, the application of these models is very helpful to predict the optimal treatment for an early application on each patient. We analyzed the transcriptome of peripheral blood mononuclear c

SUBMITTER: Oca AI 

PROVIDER: S-EPMC8706948 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature