Zebrafish Embryos and Larvae as Alternative Animal Models for Toxicity Testing.

ABSTRACT: Prerequisite to any biological laboratory assay employing living animals is consideration about its necessity, feasibility, ethics and the potential harm caused during an experiment. The imperative of these thoughts has led to the formulation of the 3R-principle, which today is a pivotal scientific standard of animal experimentation worldwide. The rising amount of laboratory investigations utilizing living animals throughout the last decades, either for regulatory concerns or for basic science, demands the development of alternative methods in accordance with 3R to help reduce experiments in mammals. This demand has resulted in investigation of additional vertebrate species displaying favourable biological properties. One prominent species among these is the zebrafish (Danio rerio),

SUBMITTER: Bauer B 

PROVIDER: S-EPMC8707050 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature