Ontology highlight
ABSTRACT:
SUBMITTER: Reinicke M
PROVIDER: S-EPMC8707069 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Reinicke Madlen M Leyh Judith J Zimmermann Silke S Chey Soroth S Brkovic Ilijana Begcevic IB Wassermann Christin C Landmann Julia J Lütjohann Dieter D Isermann Berend B Bechmann Ingo I Ceglarek Uta U
International journal of molecular sciences 20211208 24
Plant sterols (PSs) cannot be synthesized in mammals and are exclusively diet-derived. PSs cross the blood-brain barrier and may have anti-neuroinflammatory effects. Obesity is linked to lower intestinal uptake and blood levels of PSs, but its effects in terms of neuroinflammation-if any-remain unknown. We investigated the effect of high-fat diet-induced obesity on PSs in the brain and the effects of the PSs campesterol and β-sitosterol on in vitro microglia activation. Sterols (cholesterol, pre ...[more]