Characterization of NDM-1-Producing Carbapenemase in Proteus mirabilis among Broilers in China.

ABSTRACT: Carbapenem-resistant pathogens mediated by metallo-beta-lactamases (MBLs) have spread worldwide, where NDM-1 is a typical and key MBL. Here, we firstly discussed the distribution characterization of NDM-1, which produces multidrug-resistant Proteus mirabilis among broilers in China. From January to April 2019, 40 (18.1%, 40/221) bla_NDM-1-carrying P. mirabilis strains were recovered from commercial broilers in slaughterhouse B in China. All the isolates were resistant to imipenem, meropenem and other β-lactams. These isolates belong to five clusters identified via pulsed field gel electrophoresis (PFGE). Further studies on twenty representative strains revealed that seven bla_NDM-1 genes were located on plasmids with sizes of 104.5-138.9 kb.

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8707091 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature