Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota.

ABSTRACT: Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg availability modulates key bacterial functions, including growth and virulence, we investigated whether the beneficial effects of Mg supplementation during colitis might be mediated by gut microbiota. The effects of dietary Mg modulation were assessed in a murine model of dextran sodium sulfate (DSS)-induced colitis by monitoring magnesemia, weight, and fecal consistency. Gut microbiota were analyzed by 16S-rRNA based profiling on fecal samples. Mg supplementation improved microbiota richness in colitic mice, increased abundance of Bifido

SUBMITTER: Del Chierico F 

PROVIDER: S-EPMC8707433 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature