Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze.

ABSTRACT: The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined. We hypothesized that Notch is dysregulated in primary airway epithelial cells (pAEC) of children with wheeze contributing to defective repair. This study investigated transcriptional and protein expression and function of Notch in pAEC isolated from children with and without wheeze. Primary AEC of children with and without wheeze were found to express all known Notch receptors and ligands, although pAEC from children with wheeze expressed sig

SUBMITTER: Iosifidis T 

PROVIDER: S-EPMC8707470 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature