MiR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells.
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ABSTRACT:
SUBMITTER: Lombardi E
PROVIDER: S-EPMC8707697 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells.
Lombardi Elisabetta E Almanza Gonzalo G Kowal Kinga K Valvasori Marco M Agostini Francesco F Vicinanza Carla C Da Ros Francesco F Durante Cristina C Marangon Miriam M Michieli Mariagrazia M Rupolo Maurizio M Mazzucato Mario M Zanetti Maurizio M
Journal of personalized medicine 20211123 12
Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow. Despite novel therapies, MM still remains an incurable cancer and new strategies are needed. Increased expression of the transcription factor Sex-determining region Y-related high-mobility-group box transcription factor 4 (<i>SOX4</i>) has been correlated with tumor development and progression through a variety of distinct processes, including inhibition of apoptosis, increased cell invasion ...[more]
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