On the Dependence of Prion and Amyloid Structure on the Folding Environment.

ABSTRACT: Currently available analyses of amyloid proteins reveal the necessity of the existence of radical structural changes in amyloid transformation processes. The analysis carried out in this paper based on the model called fuzzy oil drop (FOD) and its modified form (FOD-M) allows quantifying the role of the environment, particularly including the aquatic environment. The starting point and basis for the present presentation is the statement about the presence of two fundamentally different methods of organizing polypeptides into ordered conformations-globular proteins and amyloids. The present study shows the source of the differences between these two paths resulting from the specificity of the external force field coming from the environment, including the aquatic and hydrophobic one. The wa

SUBMITTER: Roterman I 

PROVIDER: S-EPMC8707753 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature