Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce Preeclampsia.

ABSTRACT: Preeclampsia is a pregnancy disorder characterized by hypertension. Epidemiological studies have associated preeclampsia with an increased risk of neurodevelopmental disorders in offspring, such as autism and schizophrenia. Preeclampsia has also been linked with maternal vitamin D deficiency, another candidate risk factor also associated with autism. Our laboratory has established a gestational vitamin-D-deficient rat model that shows consistent and robust behavioural phenotypes associated with autism- and schizophrenia-related animal models. Therefore, we explored here whether this model also produces preeclampsia as a possible mediator of behavioural phenotypes in offspring. We showed that gestational vitamin D deficiency was not associated with maternal blood pressure or proteinuria dur

SUBMITTER: Ali A 

PROVIDER: S-EPMC8707812 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature