Mycobacterium abscessus Genetic Determinants Associated with the Intrinsic Resistance to Antibiotics.

ABSTRACT: Mycobacterium abscessus subsp. abscessus (MAB) is a fast-growing nontuberculous mycobacterium causing pulmonary infections in immunocompromised and immunocompetent individuals. The treatment of MAB infections in clinics is extremely challenging, as this organism is naturally resistant to most available antibiotics. There is limited knowledge on the mechanisms of MAB intrinsic resistance and on the genes that are involved in the tolerance to antimicrobials. To identify the MAB genetic factors, including the components of the cell surface transport systems related to the efflux pumps, major known elements contributing to antibiotic resistance, we screened the MAB transposon library of 2000 gene knockout mutants. The library was exposed at either minimal inhibitory (MIC) or bactericidal conce

SUBMITTER: Gorzynski M 

PROVIDER: S-EPMC8707978 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature