Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation.

ABSTRACT: Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NO_x) among PE cases and normotensive controls influence DNA methylation (EPIC array) and gene expression (RNA-seq). The study included placentas from 111 women (29 PE cases/82 controls) in Scania, Sweden. First-trimester NO_x exposure was assessed at the participants' residence using a dispersion model and categorized via median split into high or low NO_x. Placental gestational epigenetic age was derived from the DNA methylation data.

SUBMITTER: Engstrom K 

PROVIDER: S-EPMC8708250 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature