Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase.

ABSTRACT: Besides their direct effects on peripheral metabolic tissues, thyroid hormones (TH) act on the hypothalamus to modulate energy homeostasis. However, since most of the hypothalamic actions of TH have been addressed in studies with direct central administration, the estimation of the relative contribution of the central vs. peripheral effects in physiologic conditions of peripheral release (or administration) of TH remains unclear. In this study we used two different models of peripherally induced hyperthyroidism (i.e., T4 and T3 oral administration) to assess and compare the serum and hypothalamic TH status and relate them to the metabolic effects of the treatment. Peripheral TH treatment affected feeding behavior, overall growth, core body temperature, body composition, brown adipose tissu

SUBMITTER: Capelli V 

PROVIDER: S-EPMC8708331 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature