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Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na⁺ Channel 1.6 Enables Isoform-Selective Modulation.

ABSTRACT: Voltage-gated Na⁺ (Na_v) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Na_v channel α subunit that have been described (Na_v1.1-Na_v1.9), Na_v1.1, Na_v1.2, and Na_v1.6 are the primary isoforms expressed in the central nervous system (CNS). Crucially, these three CNS Na_v channel isoforms display differential expression across neuronal cell types and diverge with respect to their subcellular distributions. Considering these differences in terms of their localization, the CNS Na_v channel isoforms could represent promising targets for the development of targeted neuromodulators. However, current therapeutics that target Na_v c

SUBMITTER: Dvorak NM

PROVIDER: S-EPMC8708424 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na⁺ Channel 1.6 Enables Isoform-Selective Modulation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na⁺ Channel 1.6 Enables Isoform-Selective Modulation.