Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study.

ABSTRACT:

Background

Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.

Methods

Summary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8708510 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature