Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity.

ABSTRACT: Immune responses induced by natural infection and vaccination are known to be initiated by the recognition of microbial patterns by cognate receptors, since microbes and most vaccine components contain pathogen-associated molecular patterns. Recent discoveries on the roles of damage-associated molecular patterns (DAMPs) and cell death in immunogenicity have improved our understanding of the mechanism underlying vaccine-induced immunity. DAMPs are usually immunologically inert, but can transform into alarming signals to activate the resting immune system in response to pathogenic infection, cellular stress and death, or tissue damage. The activation of DAMPs and cell death pathways can trigger local inflammation, occasionally mediating adaptive immunity, including antibody- and cell-mediate

SUBMITTER: Lee SM 

PROVIDER: S-EPMC8708515 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature