Dataset Information

Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN₂(PhOH)CHN(C₃N₂(CH₃)₃)PhR, R = H or NO₂).

ABSTRACT: The azo-azomethine imines, R¹-N=N-R²-CH=N-R³, are a class of active pharmacological ligands that have been prominent antifungal, antibacterial, and antitumor agents. In this study, four new azo-azomethines, R¹ = Ph, R² = phenol, and R³ = pyrazol-Ph-R' (R = H or NO₂), have been synthesized, structurally characterized using X-ray, IR, NMR and UV-Vis techniques, and their antifungal activity evaluated against certified strains of Candida albicans and Cryptococcus neoformans. The antifungal tests revealed a high to moderate inhibitory activity towards both strains, which is regulated as a function of both the presence and the location of the nitro group in the aromatic ring of the series. These biologica

SUBMITTER: Fernandez D

PROVIDER: S-EPMC8708670 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN₂(PhOH)CHN(C₃N₂(CH₃)₃)PhR, R = H or NO₂).

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Dataset Information

Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN2(PhOH)CHN(C3N2(CH3)3)PhR, R = H or NO2).

OmicsDI is part of the ELIXIR infrastructure

Tweets

Synthesis, Structural Characterization, and In Vitro and In Silico Antifungal Evaluation of Azo-Azomethine Pyrazoles (PhN₂(PhOH)CHN(C₃N₂(CH₃)₃)PhR, R = H or NO₂).