Establishment Genes Present on pLS20 Family of Conjugative Plasmids Are Regulated in Two Different Ways.

ABSTRACT: During conjugation, a conjugative DNA element is transferred from a donor to a recipient cell via a connecting channel. Conjugation has clinical relevance because it is the major route for spreading antibiotic resistance and virulence genes. The conjugation process can be divided into different steps. The initial steps carried out in the donor cell culminate in the transfer of a single DNA strand (ssDNA) of the conjugative element into the recipient cell. However, stable settlement of the conjugative element in the new host requires at least two additional events: conversion of the transferred ssDNA into double-stranded DNA and inhibition of the hosts' defence mechanisms to prevent degradation of the transferred DNA. The genes involved in this late step are historically referred to as esta

SUBMITTER: Val-Calvo J 

PROVIDER: S-EPMC8708921 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature