Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study.

ABSTRACT:

Background

Lipid metabolism plays an important role in viral infections. We aimed to assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and NPC1L1 inhibitior) on COVID-19 outcomes using two-sample Mendelian randomization (MR) study.

Methods

We used two kinds of genetic instruments to proxy the exposure of lipid-lowering drugs, including expression quantitative trait loci of drugs target genes, and genetic variants within or nearby drugs target genes associated with low-density lipoprotein (LDL cholesterol from genome-wide association study). Summary-data-based MR (SMR) and inverse-variance-weighted MR (IVW-MR) were used to calculate the effect estimates.

Results

SMR analysis found that a higher expression of HMGCR was associated wi

SUBMITTER: Huang W 

PROVIDER: S-EPMC8709572 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature