Glioblastoma gene network reconstruction and ontology analysis by online bioinformatics tools.

ABSTRACT: Glioblastoma is the most aggressive type of brain tumors resistant to a number of antitumor drugs. The problem of therapy and drug treatment course is complicated by extremely high heterogeneity in the benign cell populations, the random arrangement of tumor cells, and polymorphism of their nuclei. The pathogenesis of gliomas needs to be studied using modern cellular technologies, genome- and transcriptome-wide technologies of high-throughput sequencing, analysis of gene expression on microarrays, and methods of modern bioinformatics to find new therapy targets. Functional annotation of genes related to the disease could be retrieved based on genetic databases and cross-validated by integrating complementary experimental data. Gene network reconstruction for a set of genes (proteins) prove

SUBMITTER: Gubanova NV 

PROVIDER: S-EPMC8709738 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature