An immunodominant NP_105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.

ABSTRACT: NP_105-113-B*07:02-specific CD8⁺ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP_105-113-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usage, transcriptome signature and disease severity (acute n = 77, convalescent n = 52). We demonstrated a beneficial association of NP_105-113-B*07:02-specific T cells in COVID-19 disease progression, linked with expansion of T cell precursors, high functional avidity and antiviral effector function. Broad immune

SUBMITTER: Peng Y 

PROVIDER: S-EPMC8709787 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature