Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease.

ABSTRACT:

Aims

The aim of this study was to characterize determinants of left ventricular mechanical dyssynchrony (LVMD) in patients with coronary artery disease (CAD).

Methods

Medical records and results of myocardial perfusion SPECT/CT studies were evaluated in 326 patients with previously diagnosed CAD. LVMD was assessed with the phase analysis of ECG-gated myocardial SPECT. Dyssynchrony was described with phase histogram bandwidth (PHBW), standard deviation (PHSD) or entropy (PHE) values above limit of the highest normal.

Results

Prevalence of LVMD was 29% in CAD patients. Size of the infarction scar and ischemia extent correlated significantly with PHBW, PHSD and PHE (P < 0.001 for all). Independent predictors of LVMD were myocardial infarction scar (P = 0.004), ischemia e

SUBMITTER: Hamalainen H 

PROVIDER: S-EPMC8709814 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature