Determinants of ¹⁸F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

The goal of this study was to investigate the potential determinants of ¹⁸F-NaF uptake in femoral arteries as a marker of arterial calcification in patients with type 2 diabetes and a history of arterial disease.

Methods and results

The study consisted of participants of a randomized controlled trial to investigate the effect of vitamin K2 (NCT02839044). In this prespecified analysis, subjects with type 2 diabetes and known arterial disease underwent full body ¹⁸F-NaF PET/CT. Target-to-background ratio (TBR) was calculated by dividing the mean SUV_max from both superficial femoral arteries by the SUV_mean in the superior vena cava (SVC) and calcium mass was measured on CT. The association between ¹⁸F-NaF TBR and

SUBMITTER: Takx RAP 

PROVIDER: S-EPMC8709815 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature