Imaging inflammation in atherosclerotic plaques, targeting SST₂ with [¹¹¹In]In-DOTA-JR11.

ABSTRACT:

Background

Imaging Somatostatin Subtype Receptor 2 (SST₂) expressing macrophages by [DOTA,Tyr³]-octreotate (DOTATATE) has proven successful for plaque detection. DOTA-JR11 is a SST₂ targeting ligand with a five times higher tumor uptake than DOTATATE, and holds promise to improve plaque imaging. The aim of this study was to evaluate the potential of DOTA-JR11 for plaque detection.

Methods and results

Atherosclerotic ApoE^-/- mice (n = 22) fed an atherogenic diet were imaged by SPECT/CT two hours post injection of [¹¹¹In]In-DOTA-JR11 (~ 200 pmol, ~ 50 MBq). In vivo plaque uptake of [¹¹¹In]In-DOTA-JR11 was visible in all mice, with a target-to-background-ratio (TBR) of 2.23 ± 0.35. Post-mortem scans after thymect

SUBMITTER: Meester EJ 

PROVIDER: S-EPMC8709817 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature