Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel ⁶⁸Ga-mCXCL12 PET tracer.

ABSTRACT:

Background

The chemokine receptor CXCR4 and its ligand CXCL12 have been shown to be a possible imaging and therapeutic target after myocardial infarction (MI). The murine-based and mouse-specific ⁶⁸Ga-mCXCL12 PET tracer could be suitable for serial in vivo quantification of cardiac CXCR4 expression in a murine model of MI.

Methods and results

At days 1-6 after MI, mice were intravenously injected with ⁶⁸Ga-mCXCL12. Autoradiography was performed and the infarct-to-remote ratio (I/R) was determined. In vivo PET imaging with ⁶⁸Ga-mCXCL12 was conducted on days 1-6 after MI and the percentage of the injected dose (%ID/g) of the tracer uptake in the infarct area was calculated. ¹⁸F-FDG-PET was performed for anatomical landmarking. Ex viv

SUBMITTER: Zacherl MJ 

PROVIDER: S-EPMC8709820 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature