Hyperreflective Foci and Specks Are Associated with Delayed Rod-Mediated Dark Adaptation in Nonneovascular Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Hyperreflective foci (HRF) are OCT biomarkers for the progression of nonneovascular age-related macular degeneration (AMD) attributed to anteriorly migrated retinal pigment epithelial cells. We examined associations between rod- and cone-mediated vision and HRF plus smaller hyperreflective specks (HRS); we identified a histologic candidate for HRS.

Design

Cross-sectional study and histologic survey.

Participants

Patients with healthy maculae (n = 34), early AMD (n = 26), and intermediate AMD (n = 41).

Methods

AMD severity was determined by color fundus photography. In OCT scans, HRF and HRS were counted manually. Vision tests probed cones (best-corrected visual acuity [VA], contrast sensitivity), mixed cones and rods (low-luminance VA, low-luminance def

SUBMITTER: Echols BS 

PROVIDER: S-EPMC8709925 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature