Structural and chemical heterogeneities of primary hyperoxaluria kidney stones from pediatric patients.

ABSTRACT:

Objective

Calcium oxalate stones are the most common type among stone-forming patients and in some cases result from predisposed genetic conditions. In this work, we examined the differences in structure and chemical composition between oxalate stones from patients from three groups: 1) pediatric patients that were genetically predisposed (primary hyperoxaluria) to form stones (PPH); 2) control pediatric patients that did not have such genetic predisposition (PN-PH); 3) adult patients that formed oxalate stones without the genetic predisposition (A-CaOx). A variety of instrumental analyses were conducted to identify physicochemical properties of stones characteristic of predisposed pediatric (PPH), pediatric hyperoxaluria (PN-PH), and adult (A-CaOx) patient populations.

Methods<

SUBMITTER: Du Y 

PROVIDER: S-EPMC8709938 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature