Transcriptome analysis reveals the molecular mechanism of Yiqi Rougan decoction in reducing CCl₄-induced liver fibrosis in rats.

ABSTRACT:

Background

Liver fibrosis develops from various chronic liver diseases, and there is currently a lack of specific treatment strategies. Yiqi Rougan decoction (YQRG) is a traditional Chinese medicine that has shown durative effects in the treatment of liver fibrosis; however, the mechanism associated with YQRG-related improvements in liver fibrosis remains to be experimentally determined. This study evaluated the therapeutic effect of YQRG on carbon tetrachloride (CCl₄)-induced liver fibrosis in rats and its molecular mechanism.

Methods

We used low-, medium-, and high-dose YQRG to treat CCl₄-induced liver fibrosis in rats, followed by assessment of liver injury and fibrosis according to liver appearance, body weight, liver mass index, histopathologic exa

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC8709947 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature