Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor.

ABSTRACT:

Background

Resting tremor is one of the most common symptoms of Parkinson's disease. Despite its high prevalence, resting tremor may not be as effectively treated with dopaminergic medication as other symptoms, and surgical treatments such as deep brain stimulation, which are effective in reducing tremor, have limited availability. Therefore, there is a clinical need for non-invasive interventions in order to provide tremor relief to a larger number of people with Parkinson's disease. Here, we explore whether peripheral nerve stimulation can modulate resting tremor, and under what circumstances this might lead to tremor suppression.

Methods

We studied 10 people with Parkinson's disease and rest tremor, to whom we delivered brief electrical pulses non-invasively to the median

SUBMITTER: Arruda BS 

PROVIDER: S-EPMC8709974 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature