Hedgehog signaling controls mouth opening in the amphioxus.

ABSTRACT:

Introduction

The left-sided position of the mouth in amphioxus larvae has fascinated researchers for a long time. Despite the fundamental importance of mouth development in the amphioxus, the molecular regulation of its development is almost unknown. In our previous study, we showed that Hh mutation in the amphioxus leads to no mouth opening, indicating a requirement of Hh signaling for amphioxus mouth formation. Nevertheless, since the Hh mutant also exhibits defects in early left-right (LR) patterning, it remains currently unknown whether the loss of mouth opening is affected directly by Hh deficiency or a secondary effect of its influence on LR establishment.

Results

We demonstrated that knockout of the Smo gene, another key component of the Hh signaling pathway, in the a

SUBMITTER: Hu G 

PROVIDER: S-EPMC8709984 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature