Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases.

ABSTRACT:

Background

Brain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only after symptoms develop, at which point very few treatment options are available. Therefore, patients who have an increased risk of developing brain metastasis need to be identified early. Our study aimed to identify genomic and epigenomic biomarkers for predicting brain metastasis risk in NSCLC patients.

Methods

Paired primary lung tumor tissues and either brain metastatic tissues or cerebrospinal fluid (CSF) samples were collected from 29 patients with treatment-naïve advanced NSCLC with central nervous system (CNS) metastases. A control group comprising 31 patients with advanced NSCLC who died without ever developing CNS metastasis was also inc

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8710019 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature