Serum Legumain Is Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes.

ABSTRACT:

Background

Legumain is related to carotid atherosclerotic plaques and may be a new biomarker of carotid atherosclerosis. However, the association between legumain and peripheral artery disease (PAD) of lower extremity has been less studied. This study is aimed at exploring the potential link between legumain and PAD in patients with type 2 diabetes mellitus (T2DM).

Methods

A cross-sectional study was conducted on 483 hospitalized T2DM patients. The serum legumain level was measured by a sandwich enzyme-linked immunosorbent assay. PAD was evaluated by color Doppler sonography. The association between legumain and PAD was tested by logistic regression. The predictive power of legumain for PAD was evaluated with the receiver-operating-characteristic (ROC) curve.

Results

SUBMITTER: Wei W 

PROVIDER: S-EPMC8710170 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature