Contextual processing elicits sex differences in dorsal hippocampus activation following footshock and context fear retrieval.

ABSTRACT: Establishing a contextual representation of an environment places specific spatial-temporal processing demands on the mammalian hippocampus, a region showing sex-differences in processing capabilities. However, evidence for sex differences in these processing demands during contextual fear learning remains limited. Here, we examined the relationship among contextual processing, timing of footshock, and activation of the dorsal hippocampus and basolateral amygdalar nuclei (BLA) in male and female mice (C57Bl/6 J). We modified the initial exposure time to the conditioning context prior to administration, or not, of a single footshock. We then quantified Fos- ir neurons activated by acquisition or retrieval of contextual fear memories in the rostral half of the dorsal CA1 (proximal - distal r

SUBMITTER: Colon LM 

PROVIDER: S-EPMC8710230 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature