A model for stretch growth of neurons.

ABSTRACT: In the first phase of axon growth, axons sprout from neuron bodies and are extended by the pull of the migrating growth cones towards their targets. Thereafter, once the target is reached, a lesser known second phase of axon growth ensues as the mechanical forces from the growth of the animal induce extension of the integrated axons in the process of forming tracts and nerves. Although there are several microscopic physics based models of the first phase of axon growth, to date, there are no models of the very different second phase. Here we propose a mathematical model for stretch growth of axon tracts in which the rate of production of proteins required for growth is dependent on the membrane tension. We assume that growth occurs all along the axon, and are able to predict the increase i

SUBMITTER: Purohit PK 

PROVIDER: S-EPMC8710257 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature