Impact of Comorbidities on Beneficial Effect of Lactated Ringers vs. Saline in Sepsis Patients.

ABSTRACT: Background: Lactated Ringers reduced mortality more than saline in sepsis patients but increased mortality more than saline in traumatic brain injury patients. Method: This prospective cohort study was conducted in a medical intensive care unit (ICU) in central Taiwan. We applied standard sepsis evaluation protocol and identified heart, lung, liver, kidney, and endocrine comorbidities. We also evaluated resuscitation response with central venous pressure, central venous oxygen saturation, and serum lactate level simultaneously. Propensity-score matching and Cox regression were used to estimate mortality. The competing risk model compared the lengths of hospital stays with the subdistribution hazard ratio (SHR). Results: Overall, 938 patients were included in the analys

SUBMITTER: Tseng CH 

PROVIDER: S-EPMC8710469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature