Effects of Dexmedetomidine on Postoperative Nausea and Vomiting in Adult Patients Undergoing Ambulatory Thyroidectomy: A Randomized Clinical Trial.

ABSTRACT: Background: Postoperative nausea and vomiting (PONV) is a common and disturbing problem in patients undergoing ambulatory thyroidectomy. This prospective trial aimed to explore whether dexmedetomidine (DEX) combined with azasetron (AZA) can further drop the incidence of PONV in patients undergoing ambulatory thyroidectomy compared with AZA. Methods: This single-center, randomized, double-blind trial involved 172 adult patients undergoing ambulatory thyroidectomy. The individuals were randomized to DEX + AZA group and AZA group. In the DEX + AZA group, patients received dexmedetomidine 0.5 μg kg^-1 for 10 min and then the infusion rate was held at 0.1 μg kg^-1 h^-1 until the completion of the operation, while the same amount of 0.9% saline in the

SUBMITTER: Xie C 

PROVIDER: S-EPMC8710599 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature