LncRNAs Target Ferroptosis-Related Genes and Impair Activation of CD4⁺ T Cell in Gastric Cancer.

ABSTRACT: Gastric cancer (GC) is a malignant disease of the digestive tract and a life-threatening disease worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, is reported to be highly correlated with gastric tumorigenesis and immune cell activity. However, the underlying relationship between ferroptosis and the tumor microenvironment in GC and potential intervention strategies have not been unveiled. In this study, we profiled the transcriptome and prognosis data of ferroptosis-related genes (FRGs) in GC samples of the TCGA-STAD dataset. The infiltrating immune cells in GC were estimated using the CIBERSORT and XCELL algorithms. We found that the high expression of the hub FRGs (MYB, PSAT1, TP53, and LONP1) was positively correlated with poo

SUBMITTER: Yao F 

PROVIDER: S-EPMC8710671 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature