Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.

ABSTRACT: The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. In in vitro studies, AS revealed the strong reducing power and DPPH scavenging effect, but hydroxyl radical scavenging activity and ferrous ions-chelating ability were not strong. Meanwhile, the oxidative stress RAW264.7 cell injury model was established, the low and medium-doses of AS showed significant protective effects on the viability of H₂O₂-treated cells by CCK-8 method. Besides, three doses of AS all increased the activities of SOD, CAT, and GSH-Px and decreased the MDA level compared with the H₂O₂ group, suggesting it significantly relieved

SUBMITTER: Mo YN 

PROVIDER: S-EPMC8710717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature