A mechanism-based proof of concept study on the effects of duloxetine in patients with painful knee osteoarthritis.

ABSTRACT:

Background

The global burden of osteoarthritis (OA) is steadily increasing due to demographic and lifestyle changes. The nervous system can undergo peripheral and central neuroplastic changes (sensitization) in patients with OA impacting the options to manage the pain adequately. As a result of sensitization, patients with OA show lower pressure pain thresholds (PPTs), facilitated temporal summation of pain (TSP), and impaired conditioned pain modulation (CPM). As traditional analgesics (acetaminophen and non-steroidal anti-inflammatory drugs) are not recommended for long-term use in OA, more fundamental knowledge related to other possible management regimes are needed. Duloxetine is a serotonin-noradrenalin reuptake inhibitor, and analgesic effects are documented in patients with

SUBMITTER: Ammitzboll N 

PROVIDER: S-EPMC8710922 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature