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Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications.

ABSTRACT: Enzymatic noncovalent synthesis enables the spatiotemporal control of multimolecular crowding in cells, thus offering a unique opportunity for modulating cellular functions. This article introduces some representative enzymes and molecular building blocks for generating peptide assemblies as multimolecular crowding in cells, highlights the relevant biomedical applications, such as anticancer therapy, molecular imaging, trafficking proteins, genetic engineering, artificial intracellular filaments, cell morphogenesis, and antibacterial, and briefly discusses the promises of ENS as a multistep molecular process in biology and medicine.

SUBMITTER: Yi M

PROVIDER: S-EPMC8711086 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications.

Yi Meihui M Tan Weiyi W Guo Jiaqi J Xu Bing B

Chemical communications (Cambridge, England) 20211203 96

Enzymatic noncovalent synthesis enables the spatiotemporal control of multimolecular crowding in cells, thus offering a unique opportunity for modulating cellular functions. This article introduces some representative enzymes and molecular building blocks for generating peptide assemblies as multimolecular crowding in cells, highlights the relevant biomedical applications, such as anticancer therapy, molecular imaging, trafficking proteins, genetic engineering, artificial intracellular filaments ...[more]

PMID: 34817487

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