Proteomic Screening and Verification of Biomarkers in Different Stages of Mycosis Fungoides: A pilot Study.

ABSTRACT: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; in advanced stages, it can involve multiple organs and has a poor prognosis. Early detection of the disease is still urgent, but there is no optimal therapy for advanced MF. In the present study, quantitative proteomic analyses (label-free quantitation, LFQ) were applied to tissue samples of different stages of MF and tissue samples from controls (eczema patients and healthy donors) to conduct preliminary molecular analysis to clarify the pathogenesis of the disease. Differential protein expression analysis demonstrated that 113 and 305 proteins were associated with the early and advanced stages of MF, respectively. Gene ontology (GO) enrichment analysis was conducted to determine the potential functions of the proteins,

SUBMITTER: Gan L 

PROVIDER: S-EPMC8711087 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature