Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains.

ABSTRACT:

Rationale

COPD can be assessed using multidimensional grading systems with components from three domains: pulmonary function tests, symptoms and systemic features. Clinically, measures may be used interchangeably, though it is not known if they share similar pathobiology.

Objective

To use RNA sequencing (RNA-seq) to determine if there is an overlap in the underlying biological mechanisms and consequences driving different components of the multidimensional grading systems.

Methods

Whole blood was collected for RNA-seq from current and former smokers in the Genetic Epidemiology of COPD study. We tested the overlap in gene expression and biological pathways associated with case-control status and quantitative COPD phenotypes within and between the three domains.

Resu

SUBMITTER: Ghosh AJ 

PROVIDER: S-EPMC8711128 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature