Chemoselective Electrosynthesis Using Rapid Alternating Polarity.

ABSTRACT: Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochemistry offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using direct current (DC). In contrast, applying alternating current (AC) has been known to change reaction outcomes considerably on an analytical scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here

SUBMITTER: Kawamata Y 

PROVIDER: S-EPMC8711284 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature