ELK1 Enhances Pancreatic Cancer Progression Via LGMN and Correlates with Poor Prognosis.

ABSTRACT: Pancreatic cancer is one of the most lethal cancers and its prognosis is extremely poor. Clarification of molecular mechanisms and identification of prognostic biomarkers are urgently needed. Though we previously found that LGMN was involved in pancreatic carcinoma progression, the upstream regulation of LGMN remains unknown. We used reliable software to search for the potential transcription factors that may be related with LGMN transcription, we found that ELK1 could be a new regulator of LGMN transcription that binded directly to the LGMN promoter. Moreover, knocking down of ELK1 reduced pancreatic cancer cells proliferation, invasion and survival, while LGMN restored the malignancy of pancreatic cancer in vitro and in vivo. Overexpression of ELK1 further increased cancer

SUBMITTER: Yan Q 

PROVIDER: S-EPMC8711721 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature