Have (R)-[¹¹C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies.

ABSTRACT:

Purpose

The prototypical TSPO radiotracer (R)-[¹¹C]PK11195 has been used in humans for more than thirty years to visualize neuroinflammation in several pathologies. Alternative radiotracers have been developed to improve signal-to-noise ratio and started to be tested clinically in 2008. Here we examined the scientific value of these "(R)-[¹¹C]PK11195 challengers" in clinical research to determine if they could supersede (R)-[¹¹C]PK11195.

Methods

A systematic MEDLINE (PubMed) search was performed (up to end of year 2020) to extract publications reporting TSPO PET in patients with identified pathologies, excluding studies in healthy subjects and methodological studies.

Results

Of the 288 publications selected, 152 used 13 challengers, an

SUBMITTER: Chauveau F 

PROVIDER: S-EPMC8712292 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature