Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain.

ABSTRACT:

Purpose

Translocator protein 18-kDa (TSPO) imaging with positron emission tomography (PET) is widely used in research studies of brain diseases that have a neuro-immune component. Quantification of TSPO PET images, however, is associated with several challenges, such as the lack of a reference region, a genetic polymorphism affecting the affinity of the ligand for TSPO, and a strong TSPO signal in the endothelium of the brain vessels. These challenges have created an ongoing debate in the field about which type of quantification is most useful and whether there is an appropriate simplified model.

Methods

This review focuses on the quantification of TSPO radioligands in the human brain. The various methods of quantification are summarized, including the gold standard of compa

SUBMITTER: Wimberley C 

PROVIDER: S-EPMC8712306 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature